Product Type: Inhibitor
CAS No.: 60940-34-3
MolecularFormula: C13H9NOSe
Molecular Weight: 274,18
Source: Synthetic
Purity: >99%
Solubility: Soluble in DMSO and 100% ethanol
Appearance: Off-white Solid
PubChem CID: 3194
Scientific Background: Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.
References: 1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169.2. Parnham M., Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619.3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17.4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.