Eicosapentaenoic Acid 1,2,3,4,5-13C

Formulation: A solution in methanol

Formal Name: 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic-1,2,3,4,5-13C5 acid

Purity: ≥98%

Formula Markup: C15[13C]5H30O2

Formula Weight: 307,4

Shelf life (days): 730

Notes: Eicosapentaenoic acid 1,2,3,4,5-13C (EPA 1,2,3,4,5-13C) is intended for use as an internal standard for the quantification of EPA (Item Nos. 90110 / 90110.1 / 21908) by GC- or LC-MS. EPA is an ω-3, polyunsaturated fatty acid that has been found in fish oil.{208} It inhibits RANKL-induced increases in TNF-α levels in RAW 264.7 cells when used at concentrations of 50 and 100 µM.{65736} EPA (65 pM) reduces thrombin-induced aggregation of, and increases thromboxane 3 (TXA3) levels in, platelets from isolated human platelet-rich plasma.{65737} It reduces RANKL-induced TGF-β receptor-associated protein 1 (TRAP1) stimulation of osteoclast differentiation in RAW 264.7 cells when used at concentrations of 50 and 100 µM and decreases RANKL-induced bone resorption in RAW 264.7 cells at 50 µM.{65736} EPA (50 µg/ml) decreases aspartate aminotransferase activity in dogs.{65738} It prevents reductions in brain perfusion and increases in cortical and striatal infarct volumes, as well as improves lateral coordination and posture, in a rat model of ischemia and reperfusion when administered at a dose of 100 mg/kg per day.{65739}

• Artikelnummer: CAY30017-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30017-500
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung