Product Description: Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran exhibits excellent pharmacokinetic properties in vivo. Enpatoran can be used for both innate and adaptive autoimmunity blocking research [1].
Applications: COVID-19-immunoregulation
Formula: C16H15F3N4
References: [1]Jaromir Vlach, et al. Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity. J Pharmacol Exp Ther. 2020 Dec 16;JPET-AR-2020-000275.
CAS Number: 2101938-42-3
Molecular Weight: 320.31
Compound Purity: 99.80
Research Area: Inflammation/Immunology
Solubility: DMSO : 24.44 mg/mL (ultrasonic)/Ethanol : 100 mg/mL (ultrasonic)
Target: Toll-like Receptor (TLR)
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