Ensifentrine, CAS 1884461-72-6

Formulation: A solid

Formal Name: N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-urea

Purity: ≥95%

Formula Markup: C26H31N5O4

Formula Weight: 477,6

Shelf life (days): 1460

CAS Number: 1884461-72-6

Notes: Ensifentrine is a phosphodiesterase 3 (PDE3) inhibitor (IC50 = 0.4 nM).{51365} It is selective for PDE3 over PDE4 (IC50 = 1,479 nM). Ensifentrine reduces phytohemagglutinin-induced proliferation of isolated human monocytes in a concentration-dependent manner and inhibits LPS-induced increases of TNF-α protein levels in isolated human monocytes (IC50 = 520 nM). It increases cAMP levels in isolated human neutrophils when used at a concentration of 10 µM. Ensifentrine inhibits electric field stimulation-induced contractile responses in isolated guinea pig trachea in a concentration-dependent manner. Intranasal administration of ensifentrine (25% w/w) inhibits histamine-induced bronchoconstriction and tracheal edema in guinea pigs.

• Artikelnummer: CAY38761-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38761-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe