Description: Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product is unstable in solution and is recommended to be dispensed now.
CAS Number: 571203-78-6
Formula: C30H31ClN4O4
Molecular Weight: 547,04
References: Sun Y, et al. Erastin induces apoptotic and ferroptotic cell death by inducing ROS accumulation by causing mitochondrial dysfunction in gastric cancer cell HGC‑27. Mol Med Rep. 2020 Oct;22(4):2826-2832.