ERX-41, CAS 2440087-54-5

Formulation: A solid

Formal Name: 4-[[3-(2-hydroxyethoxy)-4-nitrobenzoyl]amino]-N-[4-[[(trans-4-methylcyclohexyl)amino]carbonyl]-2-(2-methylpropoxy)phenyl]-3-(2-methylpropoxy)-benzamide

Purity: ≥98%

Formula Markup: C38H48N4O9

Formula Weight: 704,8

Shelf life (days): 730

CAS Number: 2440087-54-5

Notes: ERX-41 is an inducer of endoplasmic reticulum (ER) stress.{68260} It increases the thermal stability of lysosomal acid lipase when used at a concentration of 10 µM in the cellular thermal shift assay (CETSA) but does not inhibit lysosomal acid lipase enzymatic activity at 30 µM. ERX-41 (1 µM) increases ER tubule width, eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3/PERK) and inositol-requiring enzyme 1α (IRE1α) phosphorylation, and splicing of the gene encoding X-box binding protein 1 (XBP1) in SUM149 triple-negative breast cancer (TNBC) cells. It reduces tumor volume and weight in several patient-derived xenograft (PDX) mouse models of TNBC when administered at a dose of 10 mg/kg.

• Artikelnummer: CAY37726-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37726-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe