ETP-46321, CAS 1252594-99-2

Formulation: A solid

Formal Name: 5-[2-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamine

Purity: ≥98%

Formula Markup: C20H27N9O3S

Formula Weight: 473,6

Shelf life (days): 1460

CAS Number: 1252594-99-2

Notes: ETP-46321 is an inhibitor of PI3K p110α and p110δ (apparent Kis = 2.3 and 14.2 nM, respectively).{66300} It is selective for PI3K p110α and p110δ over p110β and p110γ (apparent Kis = 170 and 179 nM, respectively), as well as a panel of 288 kinases at 1 µM. ETP-46321 inhibits Akt phosphorylation in U2OS cells (IC50 = 8.3 nM). In vivo, ETP-43621 (50 mg/kg) reduces tumor volume in a K-RasG12V-driven murine lung tumor model. It also reduces anti-collagen IgG1 and IgG2a production, swelling, and joint rigidity in a mouse model of collagen-induced arthritis.{66301}

• Artikelnummer: CAY37330-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37330-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe