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FALZ (BPTF), His-tag Recombinant
FALZ (BPTF), His-tag Recombinant
Artikelnummer
BPS31131
Verpackungseinheit
100 µg
Hersteller
BPS Bioscience
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Encompassing Amino Acids: 2791-2911
Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Background: FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
Description: Human Fetal Alzheimer Antigen (FALZ), lso known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal His-tag, MW=15.2 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 mM imidazole, 3 mM DTT, and 10% glycerol.
Genbank: NM_182641
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: Q12830
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706.
Encompassing Amino Acids: 2791-2911
Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Background: FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
Description: Human Fetal Alzheimer Antigen (FALZ), lso known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal His-tag, MW=15.2 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 mM imidazole, 3 mM DTT, and 10% glycerol.
Genbank: NM_182641
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: Q12830
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706.
| Artikelnummer | BPS31131 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 31131 |
| Green Labware | Nein |
| Verpackungseinheit | 100 µg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
