FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027)

Formulation: 50 or 100 µl of protein A-affinity purified monoclonal antibody

Immunogen: Recombinant mouse C-terminal His-tagged CD64 extracellular domain

Clone Designation: 27

Shelf life (days): 365

Notes: CD64, also known as high-affinity immunoglobulin γ receptor I (FcγRI), is a transmembrane glycoprotein that binds the Fc region of IgG.{67216} It is composed of a ligand-binding α-chain, which contains three extracellular Ig-like domains, a transmembrane region, and a cytoplasmic domain, and two γ-chains, which contain immunoreceptor tyrosine-based activation motifs (ITAMs) that mediate signal transduction.{67217,67218,67219} CD64 is constitutively expressed in myeloid cells, including monocytes and macrophages, but can be induced in neutrophils in response to IFN-γ or G-CSF.{67220,67218} It is involved in phagocytosis, cytokine release, antibody-dependent cell-mediated cytotoxicity (ADCC), and antigen presentation to primed T cells.{67216,67221} Mouse CD64 selectively forms immune complexes with IgG2a, whereas human CD64 forms immune complexes with IgG1, IgG3, and IgG4.{67216,67222} Knockout of Fcgr1, the gene encoding CD64, inhibits clearance of B. pertussis infection in mice.{67216} Increased serum levels of CD64 are associated with sepsis.{55736} Cayman’s FcγRI/CD64 Rabbit Monoclonal Antibody can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.

• Artikelnummer: CAY37015-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37015-100
• Verpackungseinheit: 100 µl
• Mengeneinheit: STK
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Flow Cytometry, Immunocytochemistry, Reinstoffe
• Isotyp: IgG
• Wirt: Rabbit