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Applications: Useful for the study of FcRn and Fc interactions and binding kinetics.
Description: Human FcRn also known as neonatal Fc receptor is a heterodimer of FCGRT (Fc Fragment of IgG Receptor and Transporter) and B2M (beta 2 microglobulin), GenBank Accession numbers NM_001136019 and NM_004048; a.a. 24-297 and a.a. 1-119 respectively. FCGRT has a C-terminal His-Avi-tag. This protein is enzymatically biotinylated using AviTag™ technology. These proteins are co-expressed in a HEK293 expression system. MW = 48 kDa
Format: Aqueous buffer solution
Formulation: 40 mM MES pH 5.0, 120 mM NaCl and 20% glycerol.
Genbank: FcRn: NM_001136019, B2M: NM_004048
Storage Stability: At least 6 months at -80°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary use carrier protein (BSA 0.1 - 0.5%).
Tags: C-terminal His-Avi-tag
Uniprot: P55899 (FCGRT), P61769 (B2M)
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1.Roopenian, D., et al., Nature. 2007 Sep 7: 715-7252.Shields, R. et al., Biological Chemicstry. 2000 Nov; 276:6591-6604.