FdUMP (triethylammonium), CAS 134-46-3

Product Description: FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

Applications: Cancer-programmed cell death

Formula: C21H42FN4O8P

References: [1]Ghoshal K, Jacob ST. An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997;53(11):1569-1575.

CAS Number: 134-46-3

Molecular Weight: 528.55

Compound Purity: 99.96

Research Area: Cancer

Solubility: H2O : 125 mg/mL (ultrasonic)

Target: Nucleoside Antimetabolite/Analog;Thymidylate Synthase

• Artikelnummer: MEXHY-154508-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-154508-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK