FFAR4 (GPR120) (Internal) Polyclonal Antibody

Formulation: 500 μl of peptide affinity-purified polyclonal antibody

Immunogen: Synthetic peptide from the internal region of human FFAR4 (GPR120)

Shelf life (days): 1095

Notes: GPR120 is a G protein-coupled receptor (GPR) expressed in adipocytes and pro-inflammatory macrophages that is activated by long chain free fatty acids.{13205} The activation of GPR120 results in elevated calcium ions and activation of the ERK cascade.{13205} ω-3 Fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid initiate GPR120 signaling resulting in inhibition of lipopolysaccharide and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependant manner.{22326} The anti-inflammatory effects of GPR120 are indirectly involved with promoting insulin secretion.{13205} GPR120 also mediates free fatty acid induced apoptosis inhibition in the enteroendocrin cell line STC-1.{13205} Cayman’s internal polyclonal antibody detects GPR120 in LoVo and PC3 cell lysates. The predicted size for GPR120 is 42.2 kDa and the observed size is approximately 40 kDa by western blot.

• Artikelnummer: CAY14904-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14904-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µl)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting, ELISA
• Wirt: Rabbit