FGFR3 (N540K) His-Tag (Dephosphorylated), Biotin-Labeled Recombinant

Products from BPS Bioscience require a minimum order value above 400€

Encompassing Amino Acids: 397-806(end)

Background: The N540K mutation results in increased FGFR3 autophosphorylation and substrate phosphorylation, and has been linked to hypochondroplasia (short-limbed dwarfism) and impaired chondrocyte differentiation.

Description: Dephosphorylated recombinant FGFR3 (Fibroblast Growth Factor Receptor 3) encompassing amino acids 397-806. This protein contains the pathogenic mutation N540K in the tyrosine kinase domain. It also contains an N-terminal His-Tag. This protein was co-expressed with PTP1B for dephosphorylation. Phosphorylation level confirmed to be <5%. The protein is biotinylated using an N-terminal Avi-Tag™.

Formulation: 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 3 mM DTT

Genbank: NM_000142

Purity: 0,7

Storage Stability: At least 6 months at -80°C.

Supplied As: Aqueous buffer solution.

Tags: N-terminal His-tag

Uniprot: P22607

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS100921
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 100921
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK