Azido-PEG5-acid, CAS 1425973-16-5

Product Description: Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. Azido-PEG5-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: COVID-19-immunoregulation

Formula: C13H25N3O7

References: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562./[2]Zolotarskaya OY, et al. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Adv. 2015;5(72):58600-58608. Epub 2015 Jun 29.

CAS Number: 1425973-16-5

Molecular Weight: 335.35

Compound Purity: 98.0

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: ADC Linker;PROTAC Linkers

• Artikelnummer: MEXHY-130572-500
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-130572-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK