β-Glucuronide-dPBD-PEG5-NH2 (TFA), CAS 2246364-63-4

Product Description: β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity[1].

Applications: Cancer-programmed cell death

Formula: C80H102F3N7O37

References: [1]Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

CAS Number: 2246364-63-4

Molecular Weight: 1810.69

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Drug-Linker Conjugates for ADC

• Artikelnummer: MEXHY-145736A-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-145736A-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK