CL2 Linker, CAS 2270986-66-6

Product Description: CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

Applications: Cancer-programmed cell death

Formula: C68H103N11O22

References: [1]Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26./[2]Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

CAS Number: 2270986-66-6

Molecular Weight: 1426.61

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker

• Artikelnummer: MEXHY-128947-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-128947-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK