CL2A-SN-38, CAS 1279680-68-0

Product Description: CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects[1].

Applications: Cancer-programmed cell death

Formula: C73H97N11O22

References: [1]Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69./[2]Thomas M Cardillo, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

CAS Number: 1279680-68-0

Molecular Weight: 1480.61

Compound Purity: 99.07

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Drug-Linker Conjugates for ADC

• Artikelnummer: MEXHY-128946-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-128946-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK