DBCO-NHCO-PEG4-amine, CAS 1255942-08-5

Product Description: DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].

Applications: Cancer-programmed cell death

Formula: C29H37N3O6

References: [1]Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15(5):2054-2059. .

CAS Number: 1255942-08-5

Molecular Weight: 523.62

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker;PROTAC Linkers

• Artikelnummer: MEXHY-124386-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-124386-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK