DBCO-PEG5-NHS ester, CAS 2144395-59-3

Product Description: DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C36H43N3O11

References: [1]Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6490-E6497./[2]Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.

CAS Number: 2144395-59-3

Molecular Weight: 693.74

Compound Purity: 95.06

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL

Target: ADC Linker;PROTAC Linkers

• Artikelnummer: MEXHY-126885-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-126885-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK