DC41SMe, CAS 1354787-71-5

Product Description: DC41SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].

Applications: Cancer-programmed cell death

Formula: C38H36ClN5O4S2

References: [1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82./[2]Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.

CAS Number: 1354787-71-5

Molecular Weight: 726.31

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin

• Artikelnummer: MEXHY-112900-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-112900-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK