DM1-SMe, CAS 138148-68-2

Product Description: DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent agent Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines[1].

Applications: Cancer-programmed cell death

Formula: C36H50ClN3O10S2

References: [1]Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(11):1860-1867. /[2]Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41(1):98-107.

CAS Number: 138148-68-2

Molecular Weight: 784.38

Compound Purity: 98.16

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ADC Cytotoxin;Microtubule/Tubulin

• Artikelnummer: MEXHY-100128-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-100128-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK