Product Description: Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].
Applications: Cancer-programmed cell death
Formula: C26H25N3O8
References: [1]Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.
CAS Number: 118292-34-5
Molecular Weight: 507.49
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: ADC Cytotoxin;Apoptosis;Caspase