Duocarmycin DM (free base), CAS 1116745-06-2

Product Description: Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2].

Applications: Cancer-programmed cell death

Formula: C26H26ClN3O3

References: [1]Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-630./[2]Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4./[3]Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782./[4]Chen KC, Schmuck K, Tietze LF, Roffler SR. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782.

CAS Number: 1116745-06-2

Molecular Weight: 463.96

Compound Purity: 98.04

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: ADC Cytotoxin;DNA Alkylator/Crosslinker

• Artikelnummer: MEXHY-128915-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-128915-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK