Isofistularin-3

Product Description: Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin[1].

Applications: Cancer-programmed cell death

Formula: C31H30Br6N4O11

References: [1]Florean C, et al. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells. Oncotarget. 2016 Apr 26;7(17):24027-49.

Molecular Weight: 1114.01

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Apoptosis;Autophagy;DNA Methyltransferase

• Artikelnummer: MEXHY-19826-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19826-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK