m-PEG4-Br, CAS 110429-45-3

Product Description: m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

Applications: Cancer-programmed cell death

Formula: C9H19BrO4

References: [1]Walker JA, et al. Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.Bioconjug Chem. 2019 Nov 20;30(11):2982-2988.

CAS Number: 110429-45-3

Molecular Weight: 271.15

Compound Purity: 97.83

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker;PROTAC Linkers

• Artikelnummer: MEXHY-130161-1G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-130161-1G
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK