Mertansine, CAS 139504-50-0

Product Description: Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC)[1][2].

Applications: Cancer-programmed cell death

Formula: C35H48ClN3O10S

References: [1]Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules./[2]Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8./[3]Zhong P, et al. cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 2017 Jul 21;28(29):295103.

CAS Number: 139504-50-0

Molecular Weight: 738.29

Compound Purity: 99.80

Research Area: Cancer

Solubility: DMSO : 62.5 mg/mL (ultrasonic)

Target: ADC Cytotoxin;Microtubule/Tubulin

• Artikelnummer: MEXHY-19792-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19792-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK