Methotrexate (monohydrate), CAS 6745-93-3

Product Description: Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

Applications: COVID-19-anti-virus

Formula: C20H24N8O6

References: [1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73./[2]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92./[3]Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine./[4]Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

CAS Number: 6745-93-3

Molecular Weight: 472.45

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Antifolate;Apoptosis;Bacterial;DNA/RNA Synthesis

• Artikelnummer: MEXHY-14519D-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-14519D-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK