MMAF (hydrochloride), CAS 1415246-68-2

Product Description: MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A[1][2][3].

Applications: Cancer-programmed cell death

Formula: C39H66ClN5O8

Citations: Oncol Rep. 2020 Dec 9./J Control Release. 2018 May 10;277:48-56./Mol Cancer Ther. 2023 Jan 31;MCT-22-0440./Mol Ther Nucleic Acids. 2018 Mar 2;10:227-236./Patent. US20210393733A1./Research Square Preprint. 2023 Dec 4./Research Square Print. 2023 Jan 6th./Target Oncol. 2019 Oct;14(5):577-590./University of Minnesota. 2022 Sep.

References: [1]Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24./[2]Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70./[3]Lee JJ, et al. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4./[4]Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics.

CAS Number: 1415246-68-2

Molecular Weight: 768.42

Compound Purity: 99.52

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: ADC Cytotoxin;Microtubule/Tubulin

• Artikelnummer: MEXHY-15579A-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15579A-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK