Moxetumomab pasudotox, CAS 1020748-57-5

Product Description: Moxetumomab pasudotox (CAT 8015) is anti-CD22 immunotoxin containing an anti-CD22 Fv and Pseudomonas exotoxin. CD22 is a cell surface receptor expressed on a variety of malignant B-cells. Moxetumomab pasudotox can be used in the research of hairy cell leukemia (HCL)[1][2][3].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Kreitman RJ, et al. Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial. J Hematol Oncol. 2021 Feb 24;14(1):35. /[2]hillon S. Moxetumomab Pasudotox: First Global Approval. Drugs. 2018 Nov;78(16):1763-1767. /[3]Kinjyo I, et al. Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Nov;64(11):10.1002/pbc.26604. /[4]Müller F, et al. 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1867-E1875. /[5]Ksenia Matlawska-Wasowska, et al. Variability In Precursor B ALL Killing With Moxetumomab Pasudotox (CAT-8015) Linked To Differential Binding and Endocytic Trafficking. Blood (2013) 122 (21): 5022.

CAS Number: 1020748-57-5

Molecular Weight: 63500 (average)

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Antibody-Drug Conjugates (ADCs);CD22

• Artikelnummer: MEXHY-P99255-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99255-1
• Green Labware: Nein
• Verpackungseinheit: 1mg
• Mengeneinheit: STK