N3-C2-NHS ester, CAS 850180-76-6

Product Description: N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C7H8N4O4

References: [1]Gregson SJ, et al. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

CAS Number: 850180-76-6

Molecular Weight: 212.16

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ADC Linker

• Artikelnummer: MEXHY-126520-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-126520-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK