Product Description: NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].
Applications: Cancer-programmed cell death
Formula: C30H30F4N4O7
References: [1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.
CAS Number: 1817857-35-4
Molecular Weight: 634.58
Compound Purity: 99.80
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: ADC Cytotoxin;Topoisomerase