PNU-159682, CAS 202350-68-3

Product Description: PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Applications: Cancer-programmed cell death

Formula: C32H35NO13

References: [1]Quintieri L, et al. Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. Clin Cancer Res. 2005 Feb 15;11(4):1608-17./[2]Cazzamalli S, et al. Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma. Mol Cancer Ther. 2016 Dec;15(12):2926-2935./[3]Pengxuan Zhao, et al. Recent advances of antibody drug conjugates for clinical applications. Acta Pharm Sin B. 2020 Sep;10(9):1589-1600./[4]Joanne Lundy, Interim data: Phase I/IIa study of EGFR-targeted EDV nanocells carrying cytotoxic drug PNU-159682 (E-EDV-D682) with immunomodulatory adjuvant EDVs carrying α-galactosyl ceramide (EDV-GC) in patients with recurrent, metastatic pancreatic cancer. GASTROINTESTINAL CANCER—GASTROESOPHAGEAL, PANCREATIC, AND HEPATOBILIARY

CAS Number: 202350-68-3

Molecular Weight: 641.62

Compound Purity: 98.50

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

Target: ADC Cytotoxin;Topoisomerase

• Artikelnummer: MEXHY-16700-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16700-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK