SG3199, CAS 1595275-71-0

Product Description: SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)[1][2].

Applications: Cancer-programmed cell death

Formula: C33H36N4O6

References: [1]John A Hartley, et al. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. Sci Rep. 2018 Jul 11;8(1):10479./[2]Francesca Zammarchi, et al. ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies. Blood. 2018 Mar 8;131(10):1094-1105.

CAS Number: 1595275-71-0

Molecular Weight: 584.66

Compound Purity: 98.94

Research Area: Cancer

Solubility: DMSO : 130 mg/mL (ultrasonic)

Target: ADC Cytotoxin;DNA Alkylator/Crosslinker

• Artikelnummer: MEXHY-101161-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-101161-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK