SPDP, CAS 68181-17-9

Product Description: SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1][2].

Formula: C12H12N2O4S2

References: [1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7./[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.

CAS Number: 68181-17-9

Molecular Weight: 312.36

Compound Purity: 98.84

Research Area: Cancer

Solubility: DMSO : 155 mg/mL (ultrasonic)

Target: ADC Linker

• Artikelnummer: MEXHY-100216-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-100216-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK