Tesirine, CAS 1595275-62-9

Product Description: Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity[1][2].

Applications: Cancer-programmed cell death

Formula: C75H101N9O23

References: [1]Hartley JA, et al. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. Sci Rep. 2018;8(1):10479. Published 2018 Jul 11. /[2]Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24.

CAS Number: 1595275-62-9

Molecular Weight: 1496.65

Compound Purity: 98.10

Research Area: Cancer

Solubility: DMSO : 200 mg/mL (ultrasonic)

Target: DNA Alkylator/Crosslinker;Drug-Linker Conjugates for ADC

• Artikelnummer: MEXHY-128952-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-128952-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK