Thailanstatin A, CAS 1426953-21-0

Product Description: Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC[1][2][3].

Applications: Cancer-programmed cell death

Formula: C28H41NO9

References: [1]Puthenveetil S, et al. Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads. Bioconjug Chem. 2016;27(8):1880-1888./[2]Ghosh AK, et al. Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition. J Org Chem. 2018;83(9):5187-5198./[3]Liu X, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013;76(4):685-693.

CAS Number: 1426953-21-0

Molecular Weight: 535.63

Compound Purity: 99.71

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ADC Cytotoxin

• Artikelnummer: MEXHY-129589-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-129589-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK