Product Description: Val-Ala-PABC-Exatecan trifluoroacetate is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor, HY-13631). Val-Ala-PABC-Exatecan trifluoroacetate can be used for ADC molecues synthesis, such as Mal-PEGn-amide-va-Exatecan[1].
Applications: Cancer-programmed cell death
Formula: C42H44F4N6O10
References: [1]Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675.
CAS Number: 2928571-45-1
Molecular Weight: 868.83
Compound Purity: 98.39
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Drug-Linker Conjugates for ADC;Topoisomerase