CloneID: 4D5-8 (trastuzumab)
Heavy Chain modification: Fc Silent™
Antigen Long Description: A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against human HER2 (Fab) and one arm directed against human CD3e (scFv).
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P04626
Specificity Statement: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
Application Notes (Clone): This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).
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