CloneID: 4D5-8 (trastuzumab)
Antigen Long Description: A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: THIS IS A RESEARCH-GRADE BIOSIMILAR. NOT FOR HUMAN THERAPY! This recombinant Fab fragement was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P04626
Specificity Statement: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
Application Notes (Clone): This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).
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