Bleselumab, CAS 1453067-91-8

Product Description: Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd:  0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection[1].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Harland RC, et al. Efficacy and safety of bleselumab in kidney transplant recipients: A phase 2, randomized, open-label, noninferiority study. Am J Transplant. 2020 Jan;20(1):159-171. /[2]Okimura K, et al. Characterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects. Am J Transplant. 2014 Jun;14(6):1290-9. /[3]Song L, et al. Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. Transplantation. 2014 Aug 15;98(3):267-76.

CAS Number: 1453067-91-8

Molecular Weight: N/A

Compound Purity: 98.97

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Others

• Artikelnummer: MEXHY-P99257-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99257-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK