Cendakimab, CAS 2151032-62-9

Product Description: Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis)[1].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Catherine S Tripp, et al. RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study. Adv Ther. 2017 Jun;34(6):1364-1381.

CAS Number: 2151032-62-9

Molecular Weight: N/A

Compound Purity: 99.96

Research Area: Inflammation/Immunology

Solubility: H2O

Target: Interleukin Related

• Artikelnummer: MEXHY-P99496-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99496-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK