Product Description: Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes[1][2].
Applications: Metabolism-sugar/lipid metabolism
Formula: N/A
References: [1]Kostic A, et, al. A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers. Diabetes Obes Metab. 2018 Feb;20(2):283-291. /[2]Okamot H, et, al. Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys. Endocrinology. 2015 Aug;156(8):2781-94.
CAS Number: 1452387-69-7
Molecular Weight: N/A
Compound Purity: 96.61
Research Area: Metabolic Disease
Solubility: H2O
Target: GCGR