Elsilimomab, CAS 468715-71-1

Product Description: Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6), with a KD of 22 pM and an IC50 of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA)[1][2][3].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Lee JJ, et al. A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer. Mol Ther. 2014 Jul;22(7):1254-1265./[2]Burger R, et al. Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth. Haematologica. 2017 Feb;102(2):381-390./[3]Finch DK, et al. Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics. J Mol Biol. 2011 Aug 26;411(4):791-807.

CAS Number: 468715-71-1

Molecular Weight: N/A

Compound Purity: 95.00

Research Area: Cancer; Inflammation/Immunology

Solubility: H2O

Target: Interleukin Related

• Artikelnummer: MEXHY-P99287-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99287-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK