Golimumab, CAS 476181-74-5

Product Description: Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research[1][2][3].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Ueda N, et, al. The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α. Inflamm Bowel Dis. 2013 May;19(6):1224-31./[2]Pavitrakar V, et, al. Amelioration of Cisplatin-induced Renal Inflammation by Recombinant Human Golimumab in Mice. Curr Pharm Biotechnol. 2022;23(7):970-977./[3]Shealy DJ, et, al. Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α. MAbs. 2010 Jul-Aug;2(4):428-39.

CAS Number: 476181-74-5

Molecular Weight: N/A

Compound Purity: 99.68

Research Area: Cancer; Inflammation/Immunology

Solubility: H2O

Target: Apoptosis;Caspase;Interleukin Related;TNF Receptor

• Artikelnummer: MEXHY-P99111-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99111-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK