Inclacumab, CAS 1256258-86-2

Product Description: Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion[1][2][3].

Applications: Neuroscience-Neuromodulation

Formula: N/A

References: [1]Tarasev M, et al. S107: P-SELECTIN INHIBITOR INCLACUMAB REDUCES CELL ADHESION IN AN IN-VITRO ASSAYS SHOWING POTENTIAL FOR PREVENTION OF VASO-OCCLUSION EVENTS IN SICKLE CELL DISEASE. Hemasphere. 2022 Jan 31;6(Suppl ):3-4./[2]Xin Geng, et al. Inclacumab, a Fully Human Anti-P-Selectin Antibody, Directly Binds to PSGL-1 Binding Region and Demonstrates Robust and Durable Inhibition of Cell Adhesion. Blood (2020) 136 (Supplement 1): 10–11./[3]Kling D, et al. Pharmacological control of platelet-leukocyte interactions by the human anti-P-selectin antibody inclacumab--preclinical and clinical studies. Thromb Res. 2013 May;131(5):401-10.

CAS Number: 1256258-86-2

Molecular Weight: N/A

Compound Purity: 99.80

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: P-selectin

• Artikelnummer: MEXHY-P99263-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99263-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK