Iscalimab, CAS 2031153-61-2

Product Description: Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (KD: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases[1][2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: N/A

References: [1]Kahaly GJ, et al. A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, for Control of Graves Hyperthyroidism-A Proof-of-Concept Trial. J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgz013. /[2]Flandre TD, et al. Immunosuppression Profile of CFZ533 (Iscalimab), a Non-Depleting Anti-CD40 Antibody, and the Presence of Opportunistic Infections in a Rhesus Monkey Toxicology Study. Toxicol Pathol. 2022 Jul;50(5):712-724. /[3]Ristov J, et al. Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody. Am J Transplant. 2018 Dec;18(12):2895-2904. /[4]Cordoba F, et al. A novel, blocking, Fc-silent anti-CD40 monoclonal antibody prolongs nonhuman primate renal allograft survival in the absence of B cell depletion. Am J Transplant. 2015 Nov;15(11):2825-36.

CAS Number: 2031153-61-2

Molecular Weight: N/A

Compound Purity: 99.15

Research Area: Metabolic Disease; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: TNF Receptor

• Artikelnummer: MEXHY-P99670-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99670-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Konjugat: Unconjugated