Isecarosmab, CAS 2254082-79-4

Product Description: Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Siebuhr AS, et al. The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo. Int J Mol Sci. 2020 Aug 20;21(17):5992. /[2]Sharma N, et al. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. Osteoarthritis Cartilage. 2020 May;28(5):658-668. /[3]C. Brenneis. Structural and symptomatic benefit of a half-live extended, systemically applied anti-ADAMTS-5 inhibitor (M6495). 2018. 26 (1), S299-S300.

CAS Number: 2254082-79-4

Molecular Weight: N/A

Compound Purity: 96.95

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: ADAMTS

• Artikelnummer: MEXHY-P99671-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99671-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK