KY-1044, CAS 2489390-15-8

Product Description: KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response[1].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Richard C.A. Sainson, et al. An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression. Cancer Immunol Res. 2020 Dec;8(12):1568-1582.

CAS Number: 2489390-15-8

Molecular Weight: N/A

Compound Purity: 99.51

Research Area: Cancer; Inflammation/Immunology

Solubility: H2O

Target: Others

• Artikelnummer: MEXHY-P99431-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99431-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK