Modotuximab, CAS 1310460-86-6

Product Description: Modotuximab (Anti-Human EGFR Recombinant Antibody) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab contains a portion of Futuximab that binds to two independent, non-overlapping epitopes on EGFR. Modotuximab promotes cross-linking of EGFR on the cell surface and promotes EGFR cellular internalization and degradation. Modotuximab has antitumor activity in vivo[1].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]KeirST, et al. Sym004-induced EGFRelimination is associated with profound anti-tumor activity in EGFRvIIIpatient-derived glioblastoma models. J Neurooncol. 2018 Jul;138(3):489-498./[2]Modotuximab. IMGT Database.

CAS Number: 1310460-86-6

Molecular Weight: N/A

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Others

• Artikelnummer: MEXHY-P99306-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99306-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK