Onartuzumab, CAS 1133766-06-9

Product Description: Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity[1].

Applications: Cancer-Kinase/protease

Formula: N/A

References: [1]Merchant M, et al. Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2987-96./[2]Prell RA, et al. Placental and Fetal Effects of Onartuzumab, a Met/HGF Signaling Antagonist, When Administered to Pregnant Cynomolgus Monkeys. Toxicol Sci. 2018 Sep 1;165(1):186-197.

CAS Number: 1133766-06-9

Molecular Weight: N/A

Compound Purity: 99.62

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: c-Met/HGFR

• Artikelnummer: MEXHY-P99250-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99250-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK